Measure Brain Function. Improve It.
BrainYears™. Functional brain age. 643 biomarkers. Built to measure and train. Developed in collaboration with the Buck Institute for Research on Aging.
Longevity's Blind Spot
Comprehensive longevity protocols cover the body thoroughly, blood panels running past a hundred biomarkers, DEXA scans, full-body MRI, sleep and HRV tracked over time. The brain is the exception. It is the one organ system most protocols don't directly measure, despite being the single strongest predictor of how long a person will live.
2.82x
Higher mortality risk for people with the most aged brains, over 15 years.*
13.5x
Higher likelihood of an Alzheimer's diagnosis for people with the most aged brains, independent of genetics.*
*Stanford University researchers, Nature Medicine (2025), 44,498 UK Biobank participants.
The Case for a Brain Age Clock
For decades, medicine has treated the diseases of aging as if they were separate problems. Treat the cancer, then the heart attack arrives. Manage the diabetes, then Alzheimer's follows. Buck Institute President and CEO Eric Verdin calls this "whack-a-mole medicine," and argues the better approach is to target the aging process itself, before diseases appear. Many innovators and researchers are trying to model the aging process, whether across the body or one organ specifically. We've modeled it for the brain, because a younger brain is what keeps you sharp, keeps you relevant, and keeps you connected to who you are.
What Is BrainYears™?
Until now, meaningful biological brain age measurement required research-grade neuroimaging: expensive, episodic, and out of reach for most clinics, let alone individuals.
BrainYears™ Changes That
Using performance outputs, EEG, and ERP, three streams of data captured during a single active cognitive task, not just at rest, it calculates your functional brain age, which may be younger or older than your chronological age, and tracks how that trajectory changes over time. Unlike structural imaging, it measures brain function upstream of anatomical decline, when the trajectory is still reversible.
5.18 BrainYears™*
Average improvement in functional brain age after completing a Sens.ai mission
r = 0.92
Correlation between predicted and chronological age
56 Days
Duration of the intervention study behind the 5.18 BrainYears™ improvement
4.4 Years
Mean absolute error
< 0.1 BrainYears™
Test-retest repeatability: less than 1/10th of a year drift
**In an exploratory analysis, participants who engaged in Sens.ai missions showed a mean improvement of 5.18 BrainYears™ over 56 days. Assessments were administered at baseline, midway through the protocol, and again at completion. Those who didn't adhere to the protocol showed no meaningful change. Full study data is now pre-published on BioRxiv.
What It Measures
"BrainYears™ reports a single functional brain age score, plus a detailed breakdown of the four independent functional cognitive domains behind that score:
Information Processing
How quickly and accurately the brain perceives and categorizes new information. The foundation layer: every other cognitive function depends on it.
Attention
Sustained focus, task switching, and distraction filtering. Measured through lapses, variability, and recovery speed.
Self-Regulation
The brain's ability to monitor conflicting information, control impulses, and adapt after errors. A leading indicator of executive function.
Performance Output
The integration layer: overall balance of speed and accuracy across tasks. Reflects how efficiently the other three domains work together.
Beneath the headline score, the report drills into each of the four functional domains, and 20 key underlying metrics are plotted against an age-normalized distribution. You can see exactly where a client falls on each one. Within minutes of the assessment, Sens.ai's AI model delivers the full report along with personalized recommendations, so you can read the results directly and fold them into the same visit.
The Brain at Work
Your brain is processing everything around you, all at once, all the time. Someone approaches with an arm halfway raised. Handshake or hug? In the first hundred milliseconds, your brain is already filtering the details: their posture, their pace, the angle of that arm. By two hundred milliseconds, it has classified what it's seeing. By three hundred, it has committed to a response, reaching out to shake, only to catch mid-motion that both arms are opening for a hug, and adjust before you've even finished the thought. That entire sequence, filtering, classifying, deciding, inhibiting, fires dozens of times a minute, in every conversation, every drive, and right now, as you read this sentence. Event-related potentials (ERPs) are the electrical trace of exactly that sequence: the brain responding to real cognitive work, not sitting at rest.
Each step in that sequence gets slower and less reliable as the brain ages, and BrainYears™ measures all of them. Because the model reads this processing sequence directly, not a resting-state reading that shifts with mood, sleep, or caffeine, a single assessment is highly repeatable: retest it and the score drifts by less than 0.1 BrainYears. That precision makes a one-visit reading trustworthy on its own; running a new assessment on a quarterly cadence then tracks how functional brain age is actually trending over months and years.
How It's Different
Most biological age clocks measure a composite: blood proteins, DNA methylation, facial analysis. They produce a blended score across your whole body.
The next generation of aging clocks is shifting from proxies to function: modeling the aging process itself, not just its downstream effects. That shift matters because functional changes come first. By the time structural change is visible on a scan, function has often already been lost for years, and the real goal isn't just tracking decline, it's changing its trajectory.
BrainYears™ doesn't infer function from proxies. It measures it directly.
And because Sens.ai was built as a closed-loop system from day one, measurement and intervention were never separate, they're one system, by design. A brain age test without an intervention is just a number. BrainYears™ measures functional markers upstream of structural changes, before they become visible on an MRI.
Validated for Clinical Adoption
"BrainYears™ was developed in collaboration with the Buck Institute for Research on Aging, the world's leading independent research organization dedicated solely to understanding and extending healthy human longevity. As Buck Institute President and CEO Eric Verdin put it when the collaboration began: "Sens.ai's technology is a breakthrough that can help us gather the right biomarkers with high integrity to conduct the analytics and research required to progress the longevity field in the area of the brain, which is the next frontier.
The Buck Institute doesn't treat disease after it arrives. Its mission is to extend the healthy years of life, with a stated belief that people should be able to enjoy life at 95 as much as they do at 25. That mission makes it the natural home for validating a metric designed to catch cognitive aging before it becomes cognitive decline.
The BrainYears™ validation study, co-authored by Sens.ai and Buck Institute researchers, is the first wearable-derived brain age clock validated at this level of institutional rigor, a threshold that matters for clinical adoption. It is now pre-published on BioRxiv. Read the study here.
The Bigger Picture
AI can now model heart health, sleep, metabolism, and movement at scale. The brain produces more data than any of them, but until now, translating that data into something actionable has required specialist equipment, specialist expertise, and years of training.
BrainYears™ makes the brain measurable, trainable, and trackable at the same scale as the rest of the body. Not by detecting abnormalities, but by quantifying the subtle functional changes that precede structural decline; and tracking them over time, from a wearable, with a brain age clock that clinicians can act on.
That is the infrastructure layer Health AI has been missing.
Bring BrainYears™ Into Your Practice
BrainYears™ Unlimited
$4,000 USD per headset, per month, contracted annually, covering unlimited BrainYears™ assessments, unlimited in-practice Boost sessions, and the Sens.ai hardware. Built for clinics making cognitive longevity a standard part of every visit. Requires a short conversation to get started.
BrainYears™ Assessment Packs
A one-time pack of 20 pre-paid BrainYears™ assessments for a headset already on an active Professional Membership. Buy directly, no contract required.
Get a Sample BrainYears™ Report
Enter your details to receive a sample BrainYears™ report and learn next steps for bringing BrainYears™ into your practice.
Sources
¹ Verdin, E. "whack-a-mole medicine" — Marin Magazine, July 2025 ² Oh et al., "Plasma proteomics links brain and immune system aging with healthspan and longevity," Nature Medicine, 2025 (44,498 UK Biobank participants)
Disclaimer
BrainYears™ is a wellness tool that provides insight into your cognitive performance and functional brain age. It is not a medical evaluation, diagnosis, or treatment recommendation, and does not indicate the presence or absence of any disease or medical condition.